Irene Navarro Lobato
Post-Doc
ire_nl@hotmail.com
I am a biologist post-doc researcher interested in understanding how molecular and neuroanatomical substrates empower the encoding of cognitive behavior, learning and memory, and how they are disrupted in brain disorders and in neurological diseases. During my PhD under supervision of Dr. Khan at the University of Malaga, I studied the preventive effect of RGS14414 protein on memory loss and shed light on the mechanism underlying this RGS14-mediated memory enhancement. Nowadays, I have the opportunity of working in the laboratory of Dr. Genzel in order to learn electrophysiological recording in freely-moving animals. Combining molecular, histological and electrophysiological techniques, I am involved in two main projects in the lab based on modifying neural plasticity of prefrontal cortex by both extracellular matrix disruption and RGS14 protein infusions, with the goal of accelerating memory consolidation process and studying the relationship between the hippocampus and prefrontal cortex during spatial memory processing.
Scopus ID: 24171554900 | ORCID: 0000-0002-7866-3192
http://orcid.org/0000-0002-7866-3192
Publications from the lab:
I Navarro-Lobato, A Aleman-Zapata, A Samanta, Mi Bogers, S Narayanan, A Rayan, A Alonso, J van der Meij, M Khamassi, Z Khan, L Genzel, (2023) Learning Fast and Slow: Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions Elife (bioRxiv doi: https://doi.org/10.1101/2022.11.21.517356)
Alonso, A., Samanta, A., van der Meij, J., van den Brand, L., Negwer, M., Navarro Lobato, I., & Genzel, L. (2023). Defensive and offensive behaviours in a Kleefstra syndrome mouse model. Animal Cognition. doi:10.1007/s10071-023-01757-2
Samanta, A., Aleman-Zapata, A., Agarwal, K., Özsezer, P., Alonso, A., van der Meij, J., Rayan, A., Navarro-Lobato, I., & Genzel, L. (2023). CBD lengthens sleep, shortens ripples and leads to intact simple but worse cumulative memory. iScience bioRxiv, doi:10.1101/2023.02.28.530388
Alonso A, Bokeria L, van der Meij J, Samanta A, Eichler R, Spooner P, Navarro Lobato I, Genzel L (2021) The HexMaze: A previous knowledge and schema task for mice eNeuro (bioRxiv 441048)
Navarro-Lobato, I. and L. Genzel (2020). Anterior to Posterior Whole-Brain Gradient for Different Types of Memories? Trends in Neurosciences Volume 43, ISSUE 7, P451-453 DOI:https://doi.org/10.1016/j.tins.2020.04.011
Schut, Alonso, Smits, Khamassi, Samanta, Negwer, Kasri, Navarro Lobato, Genzel (2020) The Object Space Task reveals a dissociation between semantic-like and simple memory in a mouse model of Kleefstra Syndrome bioRxiv, 781054 Neurobiol Learn Mem. 173, 107265 https://doi.org/10.1016/j.nlm.2020.107265
Genzel L, Schut E, Schroeder T, Eichler R, Khamassi M, Gomez A, Navarro Lobato I, Battaglia F (2019) The Object Space Task for mice and rats (bioRxiv, 198382 2017) Plos Biology https://doi.org/10.1371/journal.pbio.3000322
Navarro-Lobato I, Genzel L. (2019) The up and down of sleep: from molecules to electrophysiology. Neurobiol Learn Mem. S1074-7427(18)30067-4. doi: 10.1016/j.nlm.2018.03.013